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Publications

Scientific publications using Canadian Longitudinal Study on Aging (CLSA) data.

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Causal relationships between plasma metabolites and prostate cancer: A Mendelian randomization study exploring immune and inflammatory mediators

HuangM, Ning D, Tong T, Teng Q, Cao F, Guan Y, Wang Y, Lei H, Pang J. Causal relationships between plasma metabolites and prostate cancer: A Mendelian randomization study exploring immune and inflammatory mediators. Current Urology. 2025 Sep 11. DOI: 10.1097/CU9.0000000000000307

The role of gut microbiota and plasma metabolites in osteoporosis: Insights from Mendelian randomization analysis

Zhu W, Ma S, Zheng X, Yin J. The role of gut microbiota and plasma metabolites in osteoporosis: Insights from Mendelian randomization analysis. Medicine (Baltimore). 2025 Sep 12;104(37):e44409. doi: 10.1097/MD.0000000000044409. PMID: 40958276; PMCID: PMC12440530.

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The Role of Plasma Metabolites in Mediating the Effect of Gut Microbiota on Obstructive Sleep Apnea: A Two-Step, Two-Sample Mendelian Randomization Study

Wang X, Zhao R, Guo J, Yang K, Xu B. The Role of Plasma Metabolites in Mediating the Effect of Gut Microbiota on Obstructive Sleep Apnea: A Two-Step, Two-Sample Mendelian Randomization Study. Nat Sci Sleep. 2025 Sep 3;17:2119-2130. doi: 10.2147/NSS.S527778. PMID: 40927699; PMCID: PMC12415091.

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Unlocking the Secrets: Causal Associations Between Blood Metabolites and Aspergillosis

Ma Y, Du W. Unlocking the Secrets: Causal Associations Between Blood Metabolites and Aspergillosis. Curr Microbiol. 2025 Sep 4;82(10):490. doi: 10.1007/s00284-025-04465-x. PMID: 40906222.

Mendelian randomisation analysis to discover plasma metabolites mediating the effect of obesity on cancer risk

Yates T, Went M, Mills C, Law P, Gockel I, Maj C, Schumacher J, Palles C, Houlston R. Mendelian randomisation analysis to discover plasma metabolites mediating the effect of obesity on cancer risk. Br J Cancer. 2025 Nov;133(9):1344-1353. doi: 10.1038/s41416-025-03170-7. Epub 2025 Sep 2. PMID: 40897820; PMCID: PMC12572173.

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Investigating Causal Links between Metabolite Profiles and Ulcerative Colitis: A Bidirectional Mendelian Randomization Study

Zarei P, Kamali Z, Keshteli AH, Sedeh PA, Vaez A. Investigating Causal Links between Metabolite Profiles and Ulcerative Colitis: A Bidirectional Mendelian Randomization Study. J Med Signals Sens. 2025 Sep 1;15:27. doi: 10.4103/jmss.jmss_16_25. PMID: 40949582; PMCID: PMC12431707.

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Plasma metabolites mediate the effects of circulating immune cell phenotypes on prostate cancer: A 2-step Mendelian randomization study

Zhou W, Ding J, Shen Y, Huang F, Xu D. Plasma metabolites mediate the effects of circulating immune cell phenotypes on prostate cancer: A 2-step Mendelian randomization study. Medicine (Baltimore). 2025 Sep 5;104(36):e44282. doi: 10.1097/MD.0000000000044282. PMID: 40922267; PMCID: PMC12419313.

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Multi-omics integration reveals CYTL1 and H6PD as key regulators of tumor metabolism in mesothelioma

Ma J, Zhang H, Yu L, Guo Y, Ming J, Guo Z. Multi-omics integration reveals CYTL1 and H6PD as key regulators of tumor metabolism in mesothelioma. Genes Genomics. 2025 Oct;47(10):1049-1063. doi: 10.1007/s13258-025-01667-2. Epub 2025 Aug 25. PMID: 40853611.

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Dissecting Causal Relationships Between Gut Microbiota, Plasma Metabolites and Bladder Cancer: A Two-Step Mendelian Randomization Study

Che K, Qian D, Cui S, Xie F. Dissecting Causal Relationships Between Gut Microbiota, Plasma Metabolites and Bladder Cancer: A Two-Step Mendelian Randomization Study. Health Sci Rep. 2025 Sep 9;8(9):e71206. doi: 10.1002/hsr2.71206. PMID: 40937009; PMCID: PMC12420358.

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Genetically predicted plasma metabolites mediate the causal role of immune cells in atrial fibrillation

Yu Y, Krause K, Zarsteck S, Cao K, Lu S, Liu Y, Zhang J. Genetically predicted plasma metabolites mediate the causal role of immune cells in atrial fibrillation. Cytokine. 2025 Dec;196:157028. doi: 10.1016/j.cyto.2025.157028. Epub 2025 Sep 16. PMID: 40961544.

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Associations between 1400 metabolites and subtypes ofendometriosis: a two-sample Mendelian randomisation study

Yan F, Chen Z, Wu L, Huang Z. Associations between 1400 metabolites and subtypes of endometriosis: a two-sample Mendelian randomisation study. J Obstet Gynaecol. 2025 Dec;45(1):2552402. doi: 10.1080/01443615.2025.2552402. Epub 2025 Aug 28. PMID: 40874543.

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Genome-wide Cox regression analysis identifies 134 novel risk loci for disability development: the Canadian Longitudinal Study on Aging and UK Biobank

Zheng H, Sun T, Wang X. Genome-wide Cox regression analysis identifies 134 novel risk loci for disability development: the Canadian Longitudinal Study on Aging and UK Biobank. J Gerontol A Biol Sci Med Sci. 2025 Sep 19;80(10):glaf185. doi: 10.1093/gerona/glaf185. PMID: 40845153.

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The CLSA data are currently available to approved public sector researchers in Canada and elsewhere. Learn more about eligibility and how to apply for access.

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